Catalog Number:

RA21003

Product Type:

Polyclonal antiserum

Immunogen Sequence:

N-terminal portion of bovine beta-Lipotropin conjugated to thyroglobulin

Host:

Rabbit

Reactivity:

Rat, Mouse, Human

Applications:

Immunohistochemistry

Description:

Work on the structure of the ACTH gene by restriction enzyme techniques showed that 6 hormones are derived from one gene: ACTH, lipotropin, alpha-MSH, beta-MSH, endorphin, and one other. Thus, extensive amino acid differences between these hormones were not adequate evidence for their being distinct. ACTH and beta-lipotropin (beta-LPH) are derived from a large precursor peptide. Each of these hormones is known to include smaller peptides having distinct biologic activities: alpha-melanotropin (alpha-MSH) and corticotropin-like intermediate lobe peptide (CLIP) are formed from ACTH; gamma-LPH and beta-endorphin are peptide components of beta-LPH.

Reference:

Owerbach, D.; Rutter, W. J.; Roberts, J. L.; Whitfeld, P.; Shine, J.; Seeburg, P. H.; Shows, T. B. : The proopiocortin (adrenocorticotropin-beta-lipotropin) gene is located on chromosome 2 in humans. Somat. Cell Genet. 7: 359-369, 1981.

Chretien, M.; Benjannet, S.; Gossard, F.; Gianoulakis, C.; Crine, P.; Lis, M.; Seidah, N. G. : From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin.'. Canad. J. Biochem. 57: 1111-1121, 1979.