Catalog Number:

RA18012

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

Phosphopeptide corresponding to residues around serine 896 of human NMDAR1.

Host:

Rabbit

Reactivity:

Rat, Mouse, Human

Applications:

Western Blot
Immunohistochemistry

Description:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. Thus, 1 class, the NMDA receptors, have N-methyl-D-aspartate as an agonist. Moriyoshi et al. (1991) cloned and characterized a cDNA encoding the rat NMDA receptor. The protein had a significant sequence similarity to the AMPA/kainate receptors and contained 4 putative transmembrane segments following a large extracellular domain. The NMDA receptor mRNA was expressed in neuronal cells throughout the brain, particularly in the hippocampus, cerebral cortex, and cerebellum. Kumar et al. (1991) isolated and characterized a protein complex of 4 major proteins that represent an intact complex of the NMDA receptor ion channel. Furthermore, they cloned the cDNA for one of the subunits of this receptor complex, the glutamate-binding protein, from rat brain;

Reference:

Genomic cloning and localization by FISH and linkage analysis of the human gene encoding the primary subunit NMDAR1 (GRIN1) of the NMDA receptor channel. Ann. Hum. Genet. 58: 95-100, 1994.

Collins, C.; Duff, C.; Duncan, A. M. V.; Planells-Cases, R.; Sun, W.; Norremolle, A.; Michaelis, E.; Montal, M.; Worton, R.; Hayden, M. R. :
Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. Genomics 17: 237-239, 1993.

During, M. J.; Symes, C. W.; Lawlor, P. A.; Lin, J.; Dunning, J.; Fitzsimons, H. L.; Poulsen, D.; Leone, P.; Xu, R.; Dicker, B. L.; Lipski, J.; Young, D. :
An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science 287: 1453-1460,