Catalog Number:

RA18007

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

Phosphopeptide corresponding to residues surrounding threonine 286 of human CaMKII. Antibodies are purified by protein A and peptide affinity chromatography.

Host:

Rabbit

Reactivity:

Rat, Mouse, Human

Applications:

Western Blot, Immunohistochemistry

Description:

Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma,and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits.

Reference:

Bayer, K.-U.; De Koninck, P.; Leonard, A. S.; Hell, J. W.; Schulman, H. : Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801-805, 2001.

Chen, C.; Rainnie, D. G.; Greene, R. W.; Tonegawa, S. : Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294, 1994.