Catalog Number:

RA18006

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

Peptide derived from the aminoterminal
region of human CaMKII.
Antibodies are purified by protein A
and peptide affinity chromatography.

Host:

Rabbit

Reactivity:

Rat, Mouse, Human, Monkey

Applications:

Western Blot

Description:

Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma,and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits.

Reference:

Bayer, K.-U.; De Koninck, P.; Leonard, A. S.; Hell, J. W.; Schulman, H. :
Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801-805, 2001.

Chen, C.; Rainnie, D. G.; Greene, R. W.; Tonegawa, S. :
Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294, 1994.