Catalog Number:

RA18003

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

Peptide corresponding to residues surrounding Thr668 of human APP695. Antibodies are purified by protein A and peptide affinity chromatography.

Host:

Rabbit

Reactivity:

Rat, Mouse, Human, Monkey

Applications:

Immunohistochemistry (paraffin), Western Blot

Description:

APP, a widely expressed cell surface protein, is cleaved in the transmembrane region by gamma-secretase. Gamma-cleavage of APP produces the extracellular amyloid beta peptide of Alzheimer disease and releases an intracellular tail fragment. The cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase TIP60. This complex potently stimulates transcription via heterologous Gal4 or LexA DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression.

Reference:

Balbin, M.; Abrahamson, M.; Gustafson, L.; Nilsson, K.; Brun, A.; Grubb, A. : A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene. Hum. Genet. 89: 580-582, 1992.

Ancolio, K.; Dumanchin, C.; Barelli, H.; Warter, J. M.; Brice, A.; Campion, D.; Frebourg, T.; Checler, F. : Unusual phenotypic alteration of beta amyloid precursor protein (beta-APP) maturation by a new val715-to-met beta-APP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc. Nat. Acad. Sci. 96: 4119-4124, 1999