Catalog Number:

RA18002

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

Phosphopeptide corresponding to residues around serine 363 of human delta opioid receptor. Antibodies are purified by protein A and peptide affinity chromatography.

Host:

Rabbit

Reactivity:

Mouse, Human

Applications:

Immunocytochemistry
Western Blot

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. The mu opioid receptor appears to mediate morphine analgesia. This receptor appears to be highly regulated and chronic ligand exposure leads to down regulation and desensitization.

Reference:

Arvidsson, U., Riedl, M., Chakrabarti, S., Lee, J. H., Nakano, A. H., Dado, R. J., Loh, H. H., Law, P. Y., Wessendorf, M. W., and Elde, R. (1995). Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci 15, 3328-41.