Catalog Number:

RA18001

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

phosphopeptide corresponding to
residues surrounding Ser377 of
human (homologous to Ser375 of
mouse) µ-opioid receptor

Host:

Rabbit

Reactivity:

Mouse, Human

Applications:

Immunoprecipitation, Immunocytochemistry, Western Blot

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. The mu opioid receptor appears to mediate morphine analgesia. This receptor appears to be highly regulated and chronic ligand exposure leads to down regulation and desensitization.

Reference:

Arvidsson, U., Riedl, M., Chakrabarti, S., Lee, J. H., Nakano, A. H., Dado, R. J., Loh, H. H., Law, P. Y., Wessendorf, M. W., and Elde, R. (1995). Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci 15, 3328-41.