Catalog Number:

RA15045

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

E. coli-derived GST-human
MMP-24 (Tyr 125 to Cys 538) fusion protein

Host:

Rabbit

Reactivity:

Human

Applications:

Immunohistochemistry, Western Blot

Description:

Matrix Metalloproteinase 24 (MMP24, MT5MMP) has been described as a proteoglycanase, which is critical in the turnover of ECM (extracellular matrix) components in the brain. MMP24 contains a candidate signal sequence, a propeptide region, a potential furin recognition motif, a zinc-binding catalytic domain, a hemopexin-like domain, a 24-residue hydrophobic region, which acts as a potential transmembrane domain, and a short cytosolic domain. Unlike other MTMMPs, MMP24 (MT5MMP) sheds from the cell surface as soluble proteinases, allowing its versatility as both a cell bound and soluble proteinase in ECM remodeling processes. MMP24 is elevated in several tumor cell lines, and is also produced by some normal cell lines. It is predominantly expressed in the brain, indicating a role in nervous system development. MMP24 is also highly expressed during embryonic development. The mouse MMP24 gene maps to chromosome 2.

Reference:

Birkedal-Hansen H et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4:197-250 (1993).

Yong VW et al. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci 21:75-80 (1998).

Borkakoti N Matrix metalloproteases: variations on a theme. Prog Biophys Mol Biol 70:73-94 (1998).

Chandler S et al. Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview. J Neuroimmunol 72:155-61 (1997).