Catalog Number:

RA15042

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

(C)EPEAEAEPEPELEPEPDPEP

Host:

Rabbit

Reactivity:

Human, Rat, Mouse

Applications:

Immunohistochemistry, Immunocytochemistry, Western Blot

Description:

Apoptosis is regulated by death domain (DD) and / or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9 and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and ?8 and inhibits the enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

Reference:

Koseki T et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A 95:5156-60 (1998).