Catalog Number:

RA14110

Product Type:

Affinity Purified Antibody

Immunogen Sequence:

(C)KASRWRGRGNREKR - Cysteine added for conjugation

Host:

Rabbit

Reactivity:

Human, Rat, Mouse

Applications:

Immunohistochemistry, Immunocytochemistry

Description:

Adrenergic receptors (ARs) react to the presence of epinephrine or adrenaline and include four general types (alpha 1, alpha 2, beta 1 and beta 2) that are found in different tissues.The coupling of ARs to intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP dependent protein kinase A and protein kinase C directed phosphorylation.

Reference:

Comings, D. E.; Gade-Andavolu, R.; Gonzalez, N.; Blake, H.; Wu, S.; MacMurray, J. P. : Additive effect of three noradrenergic genes (ADRA2A, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin. Genet. 55: 160-172, 1999.

Halperin, J. M.; Newcorn, J. H.; Koda, V. H.; Pick, L.; McKay, K. E.; Knott, P. : Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension. J. Am. Acad. Child Adolesc. Psychiat. 36: 1688-1697, 1997.

Hein, L.; Altman, J. D.; Kobilka, B. K. : Two functionally distinct alpha-2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181-184, 1999.