Catalog Number:

RA14102

Product Type:

Polyclonal antiserum

Immunogen Sequence:

CRRTESTPAGSENTKDIRL - Corresponding to residues 360-377 of the carboxy-terminus of human P2Y2

Host:

Rabbit

Reactivity:

Human, Rat, Mouse

Applications:

Immunohistochemistry, Western Blotting

Description:

P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells.

Reference:

Lustig,K.D., Shiau,A.K., Brake,A.J. and Julius,D. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. U.S.A. 90 (11), 5113-5117 (1993)

Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC and Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. U.S.A. 91 (26), 13067 (1994)