Catalog Number:

RA13100

Product Type:

Affinity Purified Antiserum

Immunogen Sequence:

EFVYEREGNTEEDEL
Corresponding to residues 1116-1130 of rat mGluR1?

Host:

Rabbit

Reactivity:

Rat, Human, Mouse, Feline

Applications:

Immunohistochemistry, Immuncytochemistry

Description:

Glutamate receptors are divided into 2 distinct classes: ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The iGluRs consist of N-methyl-D-aspartate (NMDA) receptors and non-NMDA receptors. Non-NMDA receptors are further subdivided into 2 groups: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (e.g., GRIA1) and kainate receptors (e.g., GRIK1). The mGluRs are divided into 3 groups according to agonist selectivity, coupling to different effector systems, and sequence homology. Group I includes mGluR1 and mGluR5 (GRM5), which are coupled to inositol phospholipid metabolism. Group II, which includes mGluR2 (GRM2) and mGluR3 (GRM3), and group III, which includes mGluR4 (GRM4), mGluR6 (GRM6), mGluR7 (GRM7), and mGluR8 (GRM8), are negatively coupled to adenylate cyclase activity. Each mGluR possesses a large extracellular domain.

Reference:

Reid, S. N., Romano, C., Hughes, T., and Daw, N. W. (1995). Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1 alpha and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connections. J Comp Neurol 355 (3), 470-7.