Catalog Number:

RA10111

Product Type:

Polyclonal antiserum

Immunogen Sequence:

YPFF

Host:

Rabbit

Reactivity:

Rat, Human, Monkey

Applications:

Immunohistochemistry

Description:

The immunoreactivity for endomorphin was also detected in rat brain near the mu-opiate receptor containing neurons, but the molecular form of the rat peptide has not yet been elucidated. These observations may be considered to indicate that endomorphin 1 and 2 are common mu-opiate agonists in mammals. In addition to the originally discovered mu-opiate agonistic function, these peptides have been reported to show hypotensive activity and Ca2+ channel current inhibitory activity. Endomorphins would be useful for the study of pain perception together with some other biological functions in the body.

Reference:

Pierce, T. L., and Wessendorf, M. W. (2000). Immunocytochemical mapping of endomorphin-2-immunoreactivity in rat brain. J Chem Neuroanat 18 (4), 181-207.

Zadina, J. E., Hackler, L., Ge, L. J., and Kastin, A. J. (1997). A potent and selective endogenous agonist for the mu-opiate receptor. Nature 386 (6624), 499-502.