Catalog Number:

RA10110

Product Type:

Polyclonal antiserum

Immunogen Sequence:

RASLDSEESESPPQENSC - Corresponding to residues 4-21 of the amino-terminus of rat VR1

Host:

Rabbit

Reactivity:

Rat, Mouse, Human, Monkey

Applications:

Immunhistochemistry, Immuncytochemistry, Western Blot

Description:

Vanilloid Receptor 1 (VR1), also known as capsaicin receptor, responds to both capsaicin, the pungent ingredient in hot peppers, and thermal stimuli within the noxious temperature range. This receptor is structurally related to the TRP family of ion channels and is predicted to contain 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. VR1 is highly permeable to divalent cations, including calcium and magnesium, as well as the monovalent cations sodium and potassium. Expression of VR1 appears to be limited to neurons within the sensory ganglia.

Reference:

Guo, A., Vulchanova, L., Wang, J., Li, X., an Elde, R. (1999). Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11, 946-58.

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-24.