Catalog Number:

RA10109

Product Type:

Polyclonal antiserum

Immunogen Sequence:

VEKQSTDSGAYSIGH - Corresponding to residues 383-397 of the carboxy-terminus of rat P2X3

Host:

Rabbit

Reactivity:

Rat, Human, Monkey

Applications:

Immunhistochemistry, Immuncytochemistry

Description:

P2X3 from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2 respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved.

Reference:

Brake, A. J., Wagenbach, M. J., and Julius, D. (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371, 519-23.

Vulchanova, L., Arvidsson, U., Riedl, M., Wang, J., Buell, G., Surprenant, A., North, R. A., and Elde, R. (1996). Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci U S A 93, 8063-7.

Vulchanova, L., Riedl, M. S., Shuster, S. J., Buell, G., Surprenant, A., North, R. A., and Elde, R. (1997). Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36, 1229-42.