Catalog Number:

RA10107

Product Type:

Polyclonal antiserum

Immunogen Sequence:

GLQENMRTS - Corresponding to residues 364-372 of the rat P2X1

Host:

Rabbit

Reactivity:

Rat

Applications:

Immunhistochemistry, Immuncytochemistry

Description:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.

Reference:

Vulchanova L et al. Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci U S A 93:8063-7 (1996).

Valera S et al. A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature 371:516-9 (1994).