Catalog Number:

RA10104

Product Type:

Antibody

Immunogen Sequence:

NHQLENLEAETAPLP

Host:

Rabbit

Reactivity:

Rat, Mouse, Human, Monkey

Applications:

Immunohistochemistry, Immunofluorescence, Westernblot

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. The mu opioid receptor appears to mediate morphine analgesia. This receptor appears to be highly regulated and chronic ligand exposure leads to down regulation and desensitization.

Reference:

Arvidsson, U., Riedl, M., Chakrabarti, S., Lee, J. H., Nakano, A. H., Dado, R. J.,
Loh, H. H., Law, P. Y., Wessendorf, M. W., and Elde, R. (1995). Distribution and
targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci
15, 3328-41