Catalog Number:

RA10103

Product Type:

Antibody

Immunogen Sequence:

DPAYLRDIDGMNKPV

Host:

Rabbit

Reactivity:

Human

Applications:

Immunocytochemistry

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. The kappa opioid receptor has been cloned in multiple species including mouse, rat, guinea pig, and human and is very highly conserved in these species. By coupling to inhibitory G-proteins, kappa opioid receptors cause a decrease in neuronal excitability. Kappa opioid receptors are found in brain, spinal cord, and sensory neurons. They have been shown to exist as homo- and heterodimers. Delta/kappa opioid receptor dimers appear to account for the pharmacologically described kappa-3 receptors.

Reference:

Mansson, E., Bare, L., and Yang, D. (1994). Isolation of a human kappa opioid
receptor cDNA from placenta. Biochem Biophys Res Commun 202, 1431-7.