Catalog Number:

RA10101

Product Type:

Antibody

Immunogen Sequence:

TACTPSDGPGGGAAA

Host:

Rabbit

Reactivity:

Rat, Mouse

Applications:

Immunocytochemistry

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. The delta opioid receptor is highly conserved among species and is highly expressed in brain and spinal cord. Activation of the delta opioid receptor can lead to a decrease in neuronal excitability by either decreasing calcium conductance or increasing potassium conductance by its coupling to inhibitory G-proteins. Interaction with G-proteins is thought to occur via the third intracelluar loop. Long term exposure to agonists can cause desensitization and down-regulation. Recently, delta opioid receptors have been shown to exist as both homo- and heterodimers.

Reference:

Abood, M. E., Noel, M. A., Farnsworth, J. S., and Tao, Q. (1994). Molecular cloning and
expression of a delta-opioid receptor from rat brain. J Neurosci Res 37, 714-9.

Ko, J. L., Arvidsson, U., Williams, F. G., Law, P. Y., Elde, R., and Loh, H. H. (1999). Visualization
of time-dependent redistribution of delta-opioid receptors in neuronal cells during prolonged
agonist exposure. Brain Res Mol Brain Res 69, 171-85.

Kieffer, B. L., Befort, K., Gaveriaux-Ruff, C., and Hirth, C. G. (1992). The delta-opioid receptor:
isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl
Acad Sci U S A 89, 12048-52