Catalog Number:

RA10100

Product Type:

Antibody

Immunogen Sequence:

LVPSARAELQSSPLV

Host:

Rabbit

Reactivity:

Mouse, Rat, Primate

Applications:

Immunohistochemistry: 1:1000

Description:

Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. The delta opioid receptor is highly conserved among species and is highly expressed in brain and spinal cord. Activation of the delta opioid receptor can lead to a decrease in neuronal excitability by either decreasing calcium conductance or increasing potassium conductance by its coupling to inhibitory G-proteins. Interaction with G-proteins is thought to occur via the third intracelluar loop. Long term exposure to agonists can cause desensitization and down-regulation. Recently, delta opioid receptors have been shown to exist as both homo- and heterodimers.

Reference:

Abood, M. E., Noel, M. A., Farnsworth, J. S., and Tao, Q. (1994). Molecular cloning and
expression of a delta-opioid receptor from rat brain. J Neurosci Res 37, 714-9.

Arvidsson, U., Dado, R. J., Riedl, M., Lee, J. H., Law, P. Y., Loh, H. H., Elde, R., and Wessendorf,
M. W. (1995). delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal
cord, and relationship to biogenic amines and enkephalin. J Neurosci 15, 1215-35.

Dado, R. J., Law, P. Y., Loh, H. H., and Elde, R. (1993). Immunofluorescent identification of a
delta (delta)-opioid receptor on primary afferent nerve terminals. Neuroreport 5, 341-4.