Catalog Number:

MO20000

Product Type:

Mouse monoclonal - Clone 27G12, IgG1

Immunogen Sequence:

C-terminal peptide

Host:

Mouse

Reactivity:

Rat, Human

Applications:

Immunhistochemistry

Description:

Synaptophysin is a 38kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells.

It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.

This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas,ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.

Reference:

Wiedenmann B et al. Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Am J Clin Pathol 88:560-9 (1987).

Wiedenmann B & Franke WW Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41:1017-28 (1985).