Catalog Number:

MO15040

Product Type:

Purified

Immunogen Sequence:

E. coli -derived rhSOX2

Host:

Mouse

Reactivity:

Human

Applications:

Flow Cytometry, Immunocytochemistry, Western Blotting

Description:

SOX genes compr ise a family of genes that ar e related to t he mammalian sex determining gene SRY (1–3). These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity (1–3). SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes (2). The highly complex group of SOX genes cluster at least 40 different loci that rapidly diverged in various animal lineages (4,5). At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development (3). Some are involved in human diseases, including sex reversal (3) .

Reference:

1. Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., and Wegner, M. 1998. Sox10, a novel transcriptional modulator in glial cells. J. Neurosci. 18: 237-250.

2. Arsic, N., Rajic, T., Stanojcic, S., Goodfellow, P.N., and Stevanovic, M. 1998. Characterisation and mapping of the human SOX14 gene. Cytogenet. Cell Genet. 83: 139-146.

3. Osaki, E., Nish ina, Y., Ina zawa, J., Cope land, N.G., Gilbert, D.J., Jenkins, N.A., Ohsugi, M., Tezuka, T., Yoshida, M., and Semba, K. 1999. Identification of a novel Sry-related gene and its germ c ell-spec ific expre ssion. Nu cleic Acid s Re s. 27: 2503-2510.

4. Laudet, V., Stehelin, D., and Clevers, H. 1993. Ancestry and diver sity of the HMG box superfamily. Nucle ic Acids Res. 21: 2493-2501.

5. Sasai, Y. 2001. Roles of Sox factors in neur al determination: conserved signaling in evolution? Int. J. Dev. Biol. 45: 321-326