Catalog Number:

MO15020

Product Type:

Mouse Monoclonal IgG1

Immunogen Sequence:

Recombinant chicken Paired box gene 7 (Pax7) protein (amino acids 352 - 523).

Host:

Mouse

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

Immunohistochemistry, Immunocytochemistry

Description:

PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters? anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas.
All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. Pax7 functions early in neural development to establish dorsal polarity of the neural tube, and continuous refinement of its expression affords regional identity to brain nuclei, in particular the superior colliculus. Pax7 expression within the superior colliculus is eventually restricted to the stratum griseum et fibrosum superficiale (SGFS), the retinorecipient layer to which the optic nerve projects. The key role of Pax7 in specification of the superior colliculus has been highlighted by misexpression studies which result in ectopic formation of superior collicular tissue with characteristic laminae innervated by retinal ganglion cell axons.

Reference:

Thompson J, Lovicu F, Ziman M. The role of Pax7 in determining the cytoarchitecture of the superior colliculus Dev Growth Differ. 2004 Jun;46(3):213-8.

Thomas M, Lazic S, Beazley L, Ziman M. Expression profiles suggest a role for Pax7 in the establishment of tectal polarity and map refinement Exp Brain Res. 2004 Jun;156(3):263-73. Epub 2004 Apr 27

Tanabe and Jessell Diversity and Pattern in the Developing Spinal Cord Science -274 (5290): 1115 (2001)