Catalog Number:

MO15019

Product Type:

Protein G Purified

Immunogen Sequence:

Recombinant human Leptin

Host:

Mouse IgG1

Reactivity:

Human

Applications:

Immunoghistochemistry on Paraffin sections
ELISA

Description:

Leptin is a 16kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype

Reference:

Bornstein, S. R. et al.. Immunohistochemical and Ultrastructural Localization of Leptin and Leptin Receptor in Human White Adipose Tissue and Differentiating Human Adipose Cells in Primary Culture. Diabetes; April 01, 2000;

Margetic S, Gazzola C, Pegg GG, Hill RA Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord. 2002 Nov;26(11):1407-33.