Catalog Number:

MO15018

Product Type:

Mouse Monoclonal IgG2a

Immunogen Sequence:

Recombinant human TrkA extracellular domain.

Host:

Mouse

Reactivity:

Human

Applications:

Western Blot, ELISA

Description:

Neurotrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems. Bothwell (1996), Carter and Lewin (1997), and Bibel and Barde (2000) reviewed neurotrophins and their receptors. Nerve growth factor receptor (NGFR; 162010) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4/5 (NTF5). As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF5 and BDNF, and NTF3, respectively (Ip et al., 1993). NTF3 also binds to TRKA and TRKB, but with significantly lower affinity.

Reference:

Bibel M & Barde YA Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14:2919-37 (2000).

Carter BD & Lewin GR Neurotrophins live or let die: does p75NTR decide? Neuron 18:187-90 (1997).

Bothwell M p75NTR: a receptor after all. Science 272:506-7 (1996). Ip NY et al. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10:137-49 (1993).