Catalog Number:

MO15014

Product Type:

Mouse Monoclonal IgG1 Protein G purified

Immunogen Sequence:

AEYSLFPNSPKWTSKV

Host:

Mouse

Reactivity:

Human

Applications:

Immunocytochemistry, Western Blot

Description:

Matrix metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are thus important in apoptosis, tumor cell growth, invasion, and metastasis, as well as angiogenesis and wound healing. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. MMP7, also known as matrilysin, is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normall cells, specifically glandular epithelial cells.

Reference:

Ito A et al. Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem 271:14657-60 (1996).

Fowlkes JL et al. Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis. J Biol Chem 270:27481-8 (1995).

Woessner JF Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-54 (1991).