Catalog Number:

MO15013

Product Type:

Mouse Monoclonal IgG1
Protein G purified Cell Culture Supernatant.

Immunogen Sequence:

Microtubules derived from rat brain

Host:

Mouse

Reactivity:

Human, Rat

Applications:

Immunocytochemistry, Western Blot

Description:

Microtubules are constituent parts of a diverse variety of eukaryotic cell structures, e.g., the mitotic apparatus, cilia, flagella, and elements of the cytoskeleton. They consist principally of 2 soluble proteins, alpha- and beta-tubulin, each with a molecular weight of about 55,000. They are transcribed from differe
nt genes. Using chicken alpha- and beta-tubulin cDNA,) concluded that human DNA contains about 14 copies per genome of alpha- and beta-tubulin genes. There is much evidence for evolutionary conservation of the tubulins.

Reference:

Cleveland, D. W.; Sullivan, K. F. : Molecular biology and genetics of tubulin. Ann. Rev. Biochem. 54: 331-365, 1985.

Volz, A.; Weiss, E.; Trowsdale, J.; Ziegler, A. : Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction. Hum. Genet. 93: 42-46, 1994.