Catalog Number:

HU50000

Product Type:

Affinity purified Antibody

Immunogen Sequence:

A 14 amino acid peptide sequence near the extracellular, N-terminus of human CB1 (1), conjugated to KLH

Host:

Rabbit

Reactivity:

Human

Applications:

Immunhistochemistry, Western Blot

Description:

CB1 is involved in the motivational properties of opiates and in the development of physical dependence, and extended the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.

Reference:

• Panikashvili, D.; Simeonidou, C.; Ben-Shabat, S.; Hanus, L.; Breuer, A.; Mechoulam, R.; Shohami, E. :
  An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 413: 527-531, 2001.
• Ledent, C.; Valverde, O.; Cossu, G.; Petitet, F.; Aubert, J.-F.; Beslot, F.; Bohme, G. A.; Imperato, A.; Pedrazzini, T.; Roques, B. P.; Vassart, G.; Fratta, W.; Parmentier, M. :
  Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB(1) receptor knockout mice. Science 283: :401-404, 1999.