Catalog Number:

GT15066

Product Type:

Affinity purified

Immunogen Sequence:

Recombinant mouse Artemin

Host:

Goat

Reactivity:

Mouse

Applications:

Immunohistochemistry, Immunocytochemistry
ELISA, Western Blot

Description:

Neurotrophic factors, such as GDNF, NTN, and PSPN, orchestrate multiple aspects of the development and maintenance of the central and peripheral nervous systems. These GDNF family ligands signal though a multicomponent receptor system composed of a high affinity binding component, (GFRA1-GFRA4) and a common signaling component, the RET receptor tyrosine kinase. By searching databases for sequences related to NTN, human and mouse genomic clones and cDNAs encoding a novel member of the GDNF family was identifired, which was named Artemin. Northern blot analysis revealed that Artemin is expressed at low levels in many peripheral adult tissues. Using in situ hybridization analysis of rat embryos at E14, it was found that Artemin is expressed in regions that are likely to influence the development of peripheral neurons, such as the nerve roots, but not the developing neurons, of the dorsal root ganglia. The predicted human Artemin protein contains a signal peptide and a large proregion. The mature protein contains 113 amino acids.

Reference:

Baloh, R. H.; et al.:Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex. Neuron 21: 1291-1302, 1998.

Gardell, L. R.; et al.: Multiple actions of systemic artemin in experimental neuropathy. Nature Med. 9: 1383-1389, 2003.

Honma, Y.; et al.: Artemin is a vascular-derived neurotrophic factor for developing sympathetic neurons. Neuron 35: 267-282, 2002.