Catalog Number:

GT15065

Product Type:

Affinity Purified

Immunogen Sequence:

Recombinant mouse platelet derived growth factor receptor beta extracellular domain

Host:

Goat

Reactivity:

Mouse

Applications:

ELISA, Western Blot, Immunohistochemistry on frozen sections, Immunocytochemistry

Description:

PDGF Receptor beta (CD140b) is a type I membrane protein that binds specifically to PDGF-BB form and has a tyrosine-protein kinase activity. It phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2. It is involved in a form of chronic myelomonocytic leukemia (CMML) characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML) through a chromosomal translocation t(5;12)(q33;p13) that involves PDGFRB and ETV6/TEL. It was shown that PDGF Receptor beta is also a target for adeno-associated virus type 5 (AAV-5) and bovine papillomavirus E5 protein

Reference:

Claesson-Welsh L., Eriksson A., Moren A., Severinsson L., Ek B., Oestman A., Betsholtz C., Heldin C.-H.; "cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules."; Mol. Cell. Biol. 8:3476-3486(1988).

Yokouchi M., Wakioka T., Sakamoto H., Yasukawa H., Ohtsuka S., Sasaki A., Ohtsubo M., Valius M., Inoue A., Komiya S., Yoshimura A.; "APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis."; Oncogene 18:759-767(1999).

DiMaio D, Lai CC, Mattoon D. The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein. Cytokine Growth Factor Rev. 2000 Dec;11(4):283-93

Di Pasquale, G.; Davidson, B. L.; Stein, C. S.; Martins, I.; Scudiero, D.; Monks, A.; Chiorini, J. A.: Identification of PDGFR as a receptor for AAV-5 transduction. Nature Med. 9: 1306-1312, 2003