Catalog Number:

GT15062

Product Type:

Affinity purified

Immunogen Sequence:

recombinant human TRAIL R3
extracellular domain

Host:

Goat

Reactivity:

Human

Applications:

Immunohistochemistry on paraffin sections
Western Blot, ELISA

Description:

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. DCR1 shows higher expression in normal tissues than in tumor cell lines. It is also highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Reference:

Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P., DuBose R.F., Goodwin R.G., Smith C.A.; Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.; J. Exp. Med. 186:1165-1170(1997).

Baetu TM, Hiscott J. On the TRAIL to apoptosis. Cytokine Growth Factor Rev. 2002 Jun;13(3):199-207.