Catalog Number:

GT15055

Product Type:

Affinity Purified

Immunogen Sequence:

Recombinant human Contactin-1

Host:

Goat

Reactivity:

Human, Rat

Applications:

Immunoghistochemistry, Western Blot, ELISA

Description:

Chick contactin (also known as F11 in the chick and F3 in the mouse) is a neuronal cell adhesion molecule of the immunoglobulin superfamily that is composed of 6 C2 Ig domains and 4 fibronectin type III (FN-III) repeats. In the developing mouse cerebellum, contactin is confined to discrete neuronal subpopulations and subcompartments, for example, the granule cell axons, Golgi cells, and mossy fibers, while in contrast, stellate cells and Purkinje cell bodies and dendrites are devoid of contactin expression. This restricted distribution led to the speculation that contactin is of critical importance in the formation of axon patterns in developing embryos.

Reference:

Berglund, E. O.; Murai, K. K.; Fredette, B.; Sekerkova, G.; Marturano, B.; Weber, L.; Mugnaini, E.; Ranscht, B. : Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron 24: 739-750, 1999.

2. Berglund, E. O.; Ranscht, B. : Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12. Genomics 21: 571-582, 1994.