Catalog Number:

GT15032

Product Type:

Affinity purified

Immunogen Sequence:

recombinant mouse
6X histidine-tagged Sonic Hedgehog C-terminal peptide (aa 199 - 437)

Host:

Goat

Reactivity:

Rat, Mouse

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

SHH function is required for the short-range induction of floorplate cells by the notochord. SHH function is required independently for the induction of motor neurons by both the notochord and midline neural cells. Motor neuron generation depends on 2 critical periods of SHH signaling: an early period, during which the neural plate cells are converted to ventralized progenitors, and a late period, during which SHH drives the differentiation of ventralized progenitors into motor neurons. The ambient SHH concentration during the late period determines whether ventralized progenitors differentiate into motor neurons or interneurons, thus defining the pattern of neuronal cell types generated in the neural tube.

Reference:

Agarwala, S.; Sanders, T. A.; Ragsdale, C. W. : Sonic hedgehog control of size and shape in midbrain pattern formation. Science 291: 2147-2150, 2001.

Ahlgren, S. C.; Thakur, V.; Bronner-Fraser, M. : Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc. Nat. Acad. Sci. 99: 10476-10481, 2002.

Bale, A. E.; Yu, K.-P. : The hedgehog pathway and basal cell carcinomas. Hum. Molec. Genet. 10: 757-762, 2001.

Belloni, E.; Muenke, M.; Roessler, E.; Traverso, G.; Siegel-Bartelt, J.; Frumkin, A.; Mitchell, H. F.; Donis-Keller, H.; Helms, C.; Hing, A. V.; Heng, H. H. Q.; Koop, B.; Martindale, D.; Rommens, J. M.; Tsui, L.-C.; Scherer, S. W. : Identification of Sonic Hedgehog as a candidate gene responsible for holoprosencephaly. Nature Genet. 14: 353-356, 1996.