Catalog Number:

GT15031

Product Type:

Affinity purified

Immunogen Sequence:

Recombinant mouse Resistin

Host:

Goat

Reactivity:

Mouse

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

Human Resistin is a hormone which links obesity to Type 2 diabetes. Type II diabetes , characterized by target-tissue resistance to insulin , is epidemic in industrialized societies and is strongly associated with obesity. Steppan et al. (2001) studied the mechanism by which increased adiposity causes insulin resistance. They demonstrated that adipocytes secrete a unique signaling molecule, which they called resistin (for resistance to insulin), that may be the hormone potentially linking obesity to diabetes.

Reference:

Steppan, C. M.; Bailey, S. T.; Bhat, S.; Brown, E. J.; Banerjee, R. R.; Wright, C. M.; Patel, H. R.; Ahima, R. S.; Lazar, M. A. : The hormone resistin links obesity to diabetes. Nature 409: 307-312, 2001.

Cao, H.; Hegele, R. A. : Single nucleotide polymorphisms of the resistin (RSTN) gene. J. Hum. Genet. 46: 553-555, 2001

McTernan, C. L.; McTernan, P. G.; Harte, A. L.; Levick, P. L.; Barnett, A. H.; Kumar, S. : Resistin, central obesity, and type 2 diabetes. Lancet 359: 46-47, 2002.