Catalog Number:

GT15029

Product Type:

Protein G Purified Goat IgG

Immunogen Sequence:

Recombinant rat CNTF slouble receptor alpha

Host:

Goat

Reactivity:

Rat

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

This receptor is expressed exclusively in the nervous system and skeletal muscle. The CNTF receptor was found to have a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6 (IL6). This similarity suggested that the CNTF receptor, like the IL6 receptor, requires a second, signal-transducing component. In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.

Reference:

Davis, S.; Aldrich, T. H.; Valenzuela, D. M.; Wong, V.; Furth, M. E.; Squinto, S. P.; Yancopoulos, G. D. : The receptor for ciliary neurotrophic factor. Science 253: 59-63, 1991.

DeChiara, T. M.; Vejsada, R.; Poueymirou, W. T.; Acheson, A.; Suri, C.; Conover, J. C.; Friedman, B.; McClain, J.; Pan, L.; Stahl, N.; Ip, N. Y.; Kato, A.; Yancopoulos, G. D. : Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83: 313-322, 1995