Catalog Number:

GT15028

Product Type:

Protein G Purified Goat IgG

Immunogen Sequence:

Recombinant rat CNTF

Host:

Goat

Reactivity:

Rat

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

In addition to neurotrophic effects on parasympathetic neurons, CNTF was shown to have activities on sympathetic and sensory neurons. CNTF was first characterized as a trophic factor for motor neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering from motor neuron disease. In these trials, CNTF caused unexpected and substantial weight loss, raising concerns that it might produce cachectic-like effects.

Reference:

Al-Chalabi, A.; Scheffler, M. D.; Smith, B. N.; Parton, M. J.; Cudkowicz, M. E.; Andersen, P. M.; Hayden, D. L.; Hansen, V. K.; Turner, M. R.; Shaw, C. E.; Leigh, P. N.; Brown, R. H., Jr. : Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis. Ann. Neurol. 54: 130-134, 2003.

Barbin, G.; Manthorpe, M.; Varon, S. : Purification of the chick eye ciliary neuronotrophic factor. J. Neurochem. 43: 1468-1478, 1984.

DeChiara, T. M.; Vejsada, R.; Poueymirou, W. T.; Acheson, A.; Suri, C.; Conover, J. C.; Friedman, B.; McClain, J.; Pan, L.; Stahl, N.; Ip, N. Y.; Kato, A.; Yancopoulos, G. D. : Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83: 313-322, 1995.