Catalog Number:

GT15027

Product Type:

Affinity Purified

Immunogen Sequence:

Recombinant mouse Presenilin-1 - N-terminal fragment amino acid (aa) residues 1 - 80

Host:

Goat

Reactivity:

Human

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

PS1 is localize to the nuclear membrane and associateas with interphase kinetochores and centrosomes, and suggested that the proteins play a role in chromosome organization and segregation.

Reference:

A novel presenilin 1 mutation (L174M) in a large Cuban family with early onset Alzheimer disease. Neurogenetics 4: 97-104, 2002.

Borchelt, D. R.; Thinakaran, G.; Eckman, C. B.; Lee, M. K.; Davenport, F.; Ratovitsky, T.; Prada, C.-M.; Kim, G.; Seekins, S.; Yager, D.; Slunt, H. H.; Wang, R.; Seeger, M.; Levey, A. I.; Gandy, S. E.; Copeland, N. G.; Jenkins, N. A.; Price, D. L.; Younkin, S. G; Sisodia, S. S.

Familial Alzheimer's disease-linked presenilin 1 variants elevate A-beta-1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-1013, 1996.