Catalog Number:

GT15024

Product Type:

Affinity Purified Goat IgG

Immunogen Sequence:

Recombinant rat fractalkine

Host:

Goat

Reactivity:

Mouse, Rat

Applications:

Immunohistochemistry, Western Blot

Description:

The structure, biochemical features, tissue distribution, and chromosomal localization of fractalkine indicated to Bazan et al. (1997) that it represents a unique class of chemokine that may constitute part of the molecular control of leukocyte traffic at the endothelium.

Reference:

Bazan, J. F.; Bacon, K. B.; Hardiman, G.; Wang, W.; Soo, K.; Rossi, D.; Greaves, D. R.; Zlotnik, A.; Schall, T. J. : A new class of membrane-bound chemokine with a CX3C motif. Nature 385: 640-644, 1997.

Garton, K. J.; Gough, P. J.; Blobel, C. P.; Murphy, G.; Greaves, D. R.; Dempsey, P. J.; Raines, E. W. : Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 276: 37993-38001, 2001.

Imai, T.; Hieshima, K.; Haskell, C.; Baba, M.; Nagira, M.; Nishimura, M.; Kakizaki, M.; Takagi, S.; Nomiyama, H.; Schall, T. J.; Yoshie, O. : Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530, 1997.