Catalog Number:

GT15012

Product Type:

Affinity Purified Goat IgG

Immunogen Sequence:

Recombinant mouse
Leptin receptor

Host:

Goat

Reactivity:

Mouse, Rat

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure.

Reference:

Harris RB et al. Metabolic responses to leptin in obese db/db mice are strain dependent.
Am J Physiol Regul Integr Comp Physiol 281:R115-32 (2001).

Tartaglia LA et al. Identification and expression cloning of a leptin receptor, OB-R.
Cell 83:1263-71 (1995).