Catalog Number:

GT15011

Product Type:

Affinity Purified Goat IgG

Immunogen Sequence:

Recombinant mouse Leptin

Host:

Goat

Reactivity:

Rat, Mouse, Human

Applications:

Immunohistochemistry
Western Blot
ELISA

Description:

Leptin is a 16kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Reference:

Li HY et al. Leptin immunoreactivity in the central nervous system in normal and diabetic rats.
Neuroreport 10:437-42 (1999).