Catalog Number:

GT15004

Product Type:

Affinity Purified Goat IgG

Immunogen Sequence:

Recombinant rat glial cell-line derived neurotrophic factor soluble receptor alpha 1 extracellular domain.

Host:

Goat

Reactivity:

Human, Rat

Applications:

Immunohistochemistry, Western Blot, ELISA

Description:

GDNF is a 20 kD glycosylated polypeptide that exists as a homodimer. The gene for GDNF has been mapped to human chromosome. There is significant sequence homology between rat and human GDNF. GDNF stimulates the growth of dopaminergic neurons and autonomic motor neurons. Recombinant GDNF is expressed in E. coli from a DNA sequence encoding the protein.

Reference:

Schindelhauer D et al. The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1. Genomics 28:605-7 (1995).

Krieglstein K et al. TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J 14:736-42 (1995).

Ebendal T et al. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J Neurosci Res 40:276-84 (1995).