Catalog Number:

GT15001

Product Type:

Affinity Purified Goat IgG

Immunogen Sequence:

Recombinant human neurotrophin 4

Host:

Goat

Reactivity:

Human

Applications:

Immunohistochemistry, Western Blotting, ELISA

Description:

Human NTF4, as well as a human NTF4 pseudogene, colocalized to 19q13.3 by fluorescence in situ hybridization studies. Mammalian NT4 had many unusual features compared to the previously identified neurotrophins and was less conserved evolutionarily than the others; however, mammalian NT4 displayed bioactivity and TRK receptor specificity similar to that of Xenopus NT4.
Nomenclature: Neurotrophin-5 (NTF5 or NT5) has been also referred to as neurotrophin-4 (NTF4 or NT4). Ibanez (1996) noted that confusion over the nomenclature of this factor arose because this mammalian neurotrophin is much more divergent from its amphibian counterpart (NT4) than are the other members of the family; hence the designation 'neurotrophin-5.' Subsequent studies demonstrated a functional correspondence between this protein and the amphibian NT4 protein. Some laboratories adopted the nomenclature 'neurotrophin-4/5' to denote the mammalian counterpart of Xenopus NT4.

Reference:

Ibanez, C. F. : Neurotrophin-4: the odd one out in the neurotrophin family. Neurochem. Res. 21: 787-793, 1996.

Ip, N. Y.; Ibanez, C. F.; Nye, S. H.; McClain, J.; Jones, P. F.; Gies, D. R.; Belluscio, L.; Le Beau, M. M.; Espinosa, R., III; Squinto, S. P.; Persson, H.; Yancopoulos, G. D. : Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Nat. Acad. Sci. 89: 3060-3064, 1992.