Catalog Number:

GP14105

Product Type:

Antibody

Immunogen Sequence:

(C)TASLDPDDFDPEPSDPLGSP - Corresponding to residues 285-304 of the extracellular domain rat ASIC3 [DRASIC]

Host:

Guinea Pig

Reactivity:

Rat

Applications:

Immunohistochemistry 1:1000

Description:

Acid Sensing Ion Channel (ASIC) ß is a member of the amiloride-sensitive, degenerin/epithelial sodium channel superfamily. This family of proteins has two highly hydrophobic regions and is therefore believed to have two plasma membrane-spanning domains. ASIC ß is a splice variant of ASIC. The N-terminal 172 amino acids are different from ASIC. Unlike ASIC, ASIC ß is only found in dorsal root ganglion neurons and not permeable to calcium. It is absent from brain, suggesting it has a function unique to sensory neurons.

Reference:

Sutherland SP, Benson CJ, Adelman JP, McCleskey EW. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):395-7.

Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 1997 Mar 13;386(6621):173-7.