Catalog Number:

GP14104

Product Type:

Antibody

Immunogen Sequence:

GASSEDTLLKDAAKVCL - Corresponding to residues 175-191 of soluble cytoplasmic protein human PGP9.5

Host:

Guinea Pig

Reactivity:

Rat, Mouse, Human

Applications:

Immunohistochemistry 1:500

Description:

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

Reference:

Day, I. N., Hinks, L. J., and Thompson, R. J. (1990). The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase. Biochem J 268, 521-4.

Navarro, X., Verdu, E., Wendelschafer-Crabb, G., and Kennedy, W. R. (1997). Immunohistochemical study of skin reinnervation by regenerative axons. J Comp Neurol 380, 164-74.