Catalog Number:

GP14100

Product Type:

Antibody

Immunogen Sequence:

YTGSLKPEDAEVFKDSMVPGEK
Corresponding to residues of the carboxy-terminus of rat VR1

Host:

Guinea Pig

Reactivity:

Rat

Applications:

Immunohistochemistry 1:1000

Description:

VR1 (vanilloid receptor 1) is a channel activated by capsaicin, the pungent ingredient in hot peppers. It was isolated from sensory neurons. Sequence analysis suggests that VR1 has six transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. VR1 is expressed by nociceptive sensory neurons. It is activated by noxious heat and is thought to function as transducer of noxious thermal stimuli.

Reference:

Guo, A., Vulchanova, L., Wang, J., Li, X., and Elde, R. (1999). Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11, 946-58.

Catarina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T.A., Levine, J. D., and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway [see comments]. Nature 389, 816-24.