Catalog Number:

GP10110

Product Type:

Antibody

Immunogen Sequence:

SQENPNTYSEDLDV - Corresponding to residues 245-248 of the rat proDynorphin

Host:

Guinea Pig

Reactivity:

Rat

Applications:

Immunohistochemistry 1:500

Description:

Dynorphin peptides are members of the opioid peptide family and contain the canonical opioid sequence Tyr-Gly-Gly-Phe. These peptides are derived from prodynorphin and include dynorphin A, dynorphin B and alpha neo-endorphin. Of the opioid peptides, the dynorphins have the highest affinity for the kappa opioid receptor. They are found distributed throughout the nervous system and play a role in many physiological functions.

Reference:

Arvidsson, U., Riedl, M., Chakrabarti, S., Vulchanova, L., Lee, J. H., Nakano, A. H., Lin, X., Loh, H. H., Law, P. Y., Wessendorf, M. W., and et al. (1995). The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opiods. Proc Natl Acad Sci U S A 92, 5062-6.