Catalog Number:

GP14101

Product Type:

Antibody

Immunogen Sequence:

AGSELDEGDDSPRDLV

Host:

Guinea Pig

Reactivity:

Rat

Applications:

Immunohistochemistry

Description:

Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), are known to be expressed by sensory neurons. These types of channels are of interest because low pH causes pain. ASIC Beta, a splice variant of ASIC, is found only in a subset of small and large diameter sensory neurons and is absent from sympathetic neurons or the central nervous system.

Reference:

Chen, C. C., England, S., Akopian, A. N., and Wood, J. N. (1998). A sensory neuron-specific, proton-gated ion channel. Proc Natl Acad Sci U S A 95, 10240-5.