Catalog Number:

CH14100

Product Type:

Antibody

Immunogen Sequence:

KDNFVPTNVGSEAF-NH2

Host:

Chicken

Reactivity:

Rat

Applications:

Immunohistochemistry: 1:100 -1:500

Description:

Calcitonin gene-related peptide (CGRP; a 37-amino acid neuropeptide, induces increased intracellular cAMP levels. This occurs when CGRP binds to a CGRP receptor (CRLR, or CGRPR;) after the latter is transported to the cell surface by RAMP1. CGRPR component protein, or CGRPRCP, modulates GRP responsiveness in a variety of cell types.

Reference:

Balkan, W.; Oates, E. L.; Howard, G. A.; Roos, B. A. : Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. Endocrinology 140: 1459-1469, 1999.

Evans, B. N.; Rosenblatt, M. I.; Mnayer, L. O.; Oliver, K. R.; Dickerson, I. M. : CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J. Biol. Chem. 275: 31438-31443, 2000.